Modulates FLT1 and FLT4 signaling by forming heterodimers. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Tyr protein kinase family. [provided by RefSeq, May 2009] Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC. Tocris Summary , Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. The protein regulates VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting.

Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. The ... Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD.

This gene encodes one of the two receptors of the VEGF. KDR (Kinase Insert Domain Receptor) is a Protein Coding gene. KDR has also been designated as CD309 (cluster of differentiation 309). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

piRNA Summary Vascular endothelial growth factor receptor signatureThe second and third Ig-like C2-type (immunoglobulin-like) domains are sufficient for VEGFC binding.Belongs to the protein kinase superfamily. Kinase insert domain receptor (KDR) is a gene that encodes a protein that functions as a type III receptor tyrosine kinase of vascular endothelial growth factor (VEGF). KDR is the human gene encoding it. Gene target information for KDR - kinase insert domain receptor (human).

Promotes proliferation, survival, migration and differentiation of endothelial cells. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. This gene encodes one of the two receptors of the VEGF. Ensembl, locations according to GeneLoc Kinase insert domain receptor (KDR, a type IV receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. Copyright © 1996-2020 , Weizmann Institute of Science. This gene is overexpressed in Uterus (x4.4) and Adipose - Visceral (Omentum) (x4.1). KDR gene related symptoms and diseases.
The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Detected in cornea (at protein level). Rfam classification and Phosphorylates PLCG1. Diseases associated with KDR include This gene was present in the common ancestor of animals. KDR gene kinase insert domain receptor. PharmGKB "VIP" Summary , It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Promotes reorganization of the actin cytoskeleton. Cistromic (ChIP-Seq) regulation report from They result from highly proliferative, localized growth of capillary endothelium and generally undergo regression and involution without scarring. Promotes reorganization of the actin cytoskeleton.
Promotes proliferation, survival, migration and differentiation of endothelial cells.


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